I recently had to setup Database Mail on dozens of SQL Server instances.   Rather than perform this tedious task using the SSMS GUI, I developed a script that saved me a lot of time which I'm sharing here.    My needs were simple so I only needed a single SMTP account and profile.  I decided to make the profile the default public one so that all msdb users would use this profile unless a different sp_send_dbmail @profile value was explicitly specified.  You might want to extend this script if you need other accounts/profiles, such as separate ones for administrative alerts or...