I inherited a mixed collation environment with more collations than I can count on one hand. The different collations require workarounds to avoid "cannot resolve collation conflict" errors and those workarounds kill performance due to non-sargable expressions. Dealing with mixed collations is a real pain so I strongly recommend you standardize on a single collation and deviate only after careful forethought. Here's a brief overview of collations and some guidance to help you choose the right collation for your organization and new SQL installations.
Collation Overview
A collation determines the rules SQL Server uses to compare and sort character data. These rules...